藥效學研究評價服務(Pharmacodynamics Screening Service)


1. 腫瘤藥理學研究(Tumor Pharmacodynamics Study)

運用分子生物學技術,腫瘤細胞株培養和體內裸小鼠移植瘤模型等一係列腫瘤藥效評價體係,從分子、細胞和整體動物三個水平全麵係統深入地評價覆蓋細胞毒類藥物、新生血管生成抑製劑、耐藥逆轉劑、分化誘導劑、受體或非受體型酪氨酸激酶抑製劑等分子靶向藥物的臨床前藥效及抗腫瘤作用機製研究。

Study on molecular, cellular and whole animal, use tumor efficacy evaluation system, such as molecular biology technology, tumor cell lines culturing and nude mice transplantation model and so on, to conduct preclinical drug efficacy and anti-tumor mechanism research on molecular targeted drugs which including: cytotoxic drugs, angiogenesis inhibitors, reversal agents, differentiation inducer, receptor or non-receptor tyrosine kinase inhibitors, etc.

2. 心血管係統研究(Cardiovascular Pharmacodynamics Study)

主要針對治療心肌缺血、抗心律失常、抗高血壓、抑製血小板聚集和溶血栓藥物以及抗動脈粥樣硬化和降血脂藥物的篩選及臨床前藥效學評價和機製研究。

Pre-clinical dug efficacy screening of drugs which have the following effects: myocardial ischemia treatment, anti-arrhythmia, anti-high blood pressure, inhibits platelet aggregation and thrombolytic effect, anti-atherosclerotic and blood lipid-lowering.

3. 中樞神經係統研究( Central Nervous Pharmacodynamics Study)

針對目前臨床嚴重威脅人類健康的重大疾病中風建立了缺血性腦中風(4動脈閉塞全腦缺血模型、電凝/線栓/光化學法所致大腦中動脈閉塞引起的局部性腦缺血模型)和缺氧-複氧、穀氨酸、炎症因子等誘導大腦皮層原代神經元細胞、海馬神經元細胞、腦微血管內皮細胞損傷模型,建立一係列涵蓋了從酶、受體、組織、整體動物模型到模式化動物等多個研究水平,全麵係統地對抗缺血性腦損傷藥物進行臨床前藥效學評價及作用機製研究。

Targeted on ischemic stroke, glutamic acid, anoxia-reoxygenation inflammation factor induced cell damage model, a series of enzymes, receptors, tissues, and whole animal models have been built, and then comprehensively and systematically conduct research on preclinical drug pharmacodynamics evaluation and efficacy mechanism.

4. 內分泌係統研究(Endocrine System Pharmacodynamics Study)

主要通過藥物和/或飲食誘導的Ⅰ型及Ⅱ型糖尿病模型及齧齒類動物轉基因模型,運用糖耐量和體外糖苷酶活性檢測方法、血糖鉗及分子生物學等技術全麵開展抗糖尿病及其他代謝疾病創新藥物的臨床前藥效和機製研究。

Study of drug & food induced Type Ⅰand Type Ⅱdiabetes model as well as rodents genetically modified model, use glucose tolerance, in vitro glycosidase activity detection method, blood glucose clamp and molecular biology technology to carry out comprehensive preclinical drug efficacy and mechanism research on drugs for diabetes and other metabolic diseases.

5. 消化係統藥物藥效評價(Digestive System Pharmacodynamics Study)

建立化學損傷、應激損傷和免疫損傷引起的胃、腸潰瘍模型;體內、外觀察胃、腸運動和動作電位實驗方法。

Establish gastric ulcer and enterelcosis model induced by chemical damage, stress damage and immune injury.

6. 其他係統藥效評價(Pharmacodynamics Study on other system)

l 呼吸係統藥物藥效評價(Respiratory system pharmacodynamics study)

l 良性前列腺增生藥物藥效評價(Benign prostatic hypertrophy pharmacodynamics study)

l 皮膚疾病藥效學評價模型(Skin disease pharmacodynamics study)


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